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The c-MYC-WDR43 signalling axis promotes chemoresistance and tumour growth in colorectal cancer by inhibiting p53 activity

期刊: DRUG RESISTANCE UPDATES, 2023; 66 ()

Oxaliplatin chemoresistance is a major challenge in the clinical treatment of colorectal cancer (CRC), which is one of the most common malignancies wo......

Perspectives on drug repurposing to overcome cancer multidrug resistance mediated by ABCB1 and ABCG2

期刊: DRUG RESISTANCE UPDATES, 2023; 71 ()

The overexpression of the human ATP-binding cassette (ABC) transporters in cancer cells is a common mechanism involved in developing multidrug resista......

Targeting Myc-driven stress addiction in colorectal cancer

期刊: DRUG RESISTANCE UPDATES, 2023; 69 ()

MYC is a proto-oncogene that encodes a powerful regulator of transcription and cellular programs essential for normal development, as well as the grow......

Regulation of cisplatin resistance in bladder cancer by epigenetic mechanisms

期刊: DRUG RESISTANCE UPDATES, 2023; 68 ()

Bladder cancer is one of the most common malignancies in the world. Cisplatin is one of the most potent and widely used anticancer drugs and has been ......

Radioiodine therapy in advanced differentiated thyroid cancer: Resistance and overcoming strategy

期刊: DRUG RESISTANCE UPDATES, 2023; 68 ()

Thyroid cancer is the most prevalent endocrine tumor and its incidence is fast-growing worldwide in recent years. Differentiated thyroid cancer (DTC) ......

CRISPR/Cas9 screens unravel miR-3689a-3p regulating sorafenib resistance in hepatocellular carcinoma via suppressing CCS/SOD1-dependent mitochondrial oxidative stress

期刊: DRUG RESISTANCE UPDATES, 2023; 71 ()

Aims: Therapeutic outcome of sorafenib in hepatocellular carcinoma (HCC) is undermined by the development of drug resistance. This study aimed to iden......

Opposite evolution of pathogenicity driven by in vivo wzc and wcaJ mutations in ST11-KL64 carbapenem-resistant Klebsiella pneumoniae

期刊: DRUG RESISTANCE UPDATES, 2023; 66 ()

Aims: To investigate the in vivo evolution of the mucoid-phenotype of ST11-KL64 carbapenem-resistant Klebsiella pneumoniae (CRKP) isolated from the sa......

Purinergic signalling in cancer therapeutic resistance: From mechanisms to targeting strategies

期刊: DRUG RESISTANCE UPDATES, 2023; 70 ()

Purinergic signalling, consisting of extracellular purines and purinergic receptors, modulates cell proliferation, invasion and immunological reaction......

Acquired non-thermal plasma resistance mediates a shift towards aerobic glycolysis and ferroptotic cell death in melanoma

期刊: DRUG RESISTANCE UPDATES, 2023; 67 ()

Aims: To gain insights into the underlying mechanisms of NTP therapy sensitivity and resistance, using the firstever NTP-resistant cell line derived f......

Hallmarks of anticancer and antimicrobial activities of corroles

期刊: DRUG RESISTANCE UPDATES, 2023; 67 ()

Corroles provide a remarkable opportunity for the development of cancer theranostic agents among other por-phyrinoids. While most transition metal cor......

Fighting drug-resistant lung cancer by induction of NAD(P)H:quinone oxidoreductase 1 (NQO1)-mediated ferroptosis

期刊: DRUG RESISTANCE UPDATES, 2023; 70 ()

Drug resistance is a major challenge in cancer treatment. The substrates of NAD(P)H:quinone oxidoreductase 1 (NQO1) show a promising anticancer effect......

Targeting ACYP1-mediated glycolysis reverses lenvatinib resistance and restricts hepatocellular carcinoma progression

期刊: DRUG RESISTANCE UPDATES, 2023; 69 ()

Acylphosphatase 1 (ACYP1), a protein located in the mammalian cell cytoplasm, has been shown to be associated with tumor initiation and progression by......

Elevated NOX4 promotes tumorigenesis and acquired EGFR-TKIs resistance via enhancing IL-8/PD-L1 signaling in NSCLC

期刊: DRUG RESISTANCE UPDATES, 2023; 70 ()

Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have been widely used for human non-small-cell lung cancer (NSCLC) treatment......

Carbapenemase-loaded outer membrane vesicles protect Pseudomonas aeruginosa by degrading imipenem and promoting mutation of antimicrobial resistance gene

期刊: DRUG RESISTANCE UPDATES, 2023; 68 ()

Aims: To investigate the effect of Klebsiella pneumoniae carbapenemase (KPC)-loaded outer membrane vesicles (OMVs) in protecting Pseudomonas aeruginos......

Overexpression of blaGES-1 due to a strong promoter in the class 1 integron contributes to decreased ceftazidime-avibactam susceptibility in carbapenem-resistant Pseudomonas aeruginosa ST235

期刊: DRUG RESISTANCE UPDATES, 2023; 69 ()

Sequence type 235 (ST235) Pseudomonas aeruginosa, harboring so-called international, high-risk, or widespread clones, is associated with relatively hi......

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